(2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). After that we decided to just go straight to IVF given the chance of successful pregnancy with IUI was very low. Of course the quality of the embryo is everything but there is significantly more uterine prep with a frozen transfer and I think it helped. This ended up working for me after my biochemical pregnancy. Sorry to hear about your recent cycle. TTC 3 years (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. Weve spent almost 45K on this process and we are with a reputable clinic affiliated with CCRM so I am confident they know what they are doing but you cant also help but wonder is there more that can be done Im waiting to hear from the team to see if shes given some more thoughts. In my case, my miscarriage was potentially caused by a partial uterine septate that my doctor identified via sonohystergram and removed via hysteroscopy. How does anyone not go completely crazy through this whole process???? The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). I'm super bummed about it being a chemical, but I still feel like progress was made because this was my first positive pregnancy test EVER. Thankful for these forums! Definitely heartbroken but trying to look forward. , ERA was a game changer for me! I am so so sorry. HCG was 24 Friday and yesterday went down to 16. After the first, we did the era and added the endo scratch. Recurrent Chemical Pregnancy - PGS embryo (and Donor egg ) Advice needed. Please don't give up! Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. Best of luck to you. Did your RE have you take anything other than progesterone and estrogen and aspirin? Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. Hi, i didnt have chemicals, I had bfn for my first two transfers. No PGS testing After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. This isnt very surprising considering these embryos have no cells that are euploid in order to self-correct (read more about that here). You may want to ask/consider this before moving on for more data before trying with another precious embryo. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). Thanks so much in advance for any feedback. But what about the women who didnt get blasts? Im very sorry and hope you can find the strength to continue. (2017)had similar results to above (aCGH, women <35): Capalbo et al. My doctor told me you can have an infection in the uterus and have no symptoms. Im so sorry to hear about your losses but so happy with your current miracle. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. Would you ladies push next time for a different protocol? As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). Obviously this is not an ideal situation but sometimes this happens. Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. I can totally see not doing it though. Thought just because your embryo iseuploidthat grades dont matter anymore? great to know! Do embryo biopsies for PGT-A match the rest of the embryo? An embryo forms and may even embed in your uterus lining (implantation), but then it stops developing. I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. PGS can increase the rate of clinical pregnancy. I paid a fortune for those sessions (I dont have insurance). PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. After my negative, we did ERA and had a hysteroscopy to correct a small septum. While those are great odds, sometimes the FET fails. I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. Once they see it on an U/S, I think it becomes a clinical pregnancy. They found that: If you want to read my summary of this paper, check here. The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. Im sure that data exists especially since thats how things used to be done back in the day. Im trying not to fixate on my last embryo being a day 7. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. During my first IVF cycle, when we only created 2 normal embryos out of 18 eggs (my husband's sperm is great), it seemed like embryo quality would have explained the first two chemical pregnancies. 35 years old I know it only takes one good embryo to be successful and I understand the odds of having a good enough embryo to send for testing and having that testing turn out normal is very small. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. I will ask my dr about this. Im so confused as my RE says that morphology doesnt matter if theyre euploid. What are the differences between the two tests? (2016)found nostatistically significantdifference inongoing pregnanciesbetween Day 5 and 6 euploids (78.6% vs 67.4%), but this was reduced by Day 7 (43.8%). Create an account or log in to participate. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. We have one day 7/Euploid Blast 5BB remaining on ice. in reply to 3 years ago Thank you so much! Find advice, support and good company (and some stuff just for fun). Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. MENT I got a natural BFP at 34yo with an FSH of 38 and had no issues with my pregnancy. Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). Yes, and I believe it was due to doctor negligence. We are absolutely crushed. On September 20th, we did my first IVF cycle. I have a whole page dedicated to mosaic embryos. So maybe youve had a cycle and your embryos are frozen, and now you want them biopsied. We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". Id say if you feel you want the extra testing, push for it. My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. I had another hysteroscopy after my chemical but b/c it had been nearly 2 years since I had one when i started IVF. Zhao et al. I am 42. In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. Its basically a mock FET but instead of transferring an embryo they take a biopsy of your uterus to see if it was ready for implantation at the time or needs more/less progesterone. But wait! Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). (2018)found a reduction in clinical pregnancy when embryos were thawed, biopsied and re-frozen (the odds were about half). Best of luck! 2018). Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. Ive done 4 transfers now with PGS tested embryos - the first failed and the last 3 resulted in chemical pregnancies. 4 PGT-M and PGT-A vs. Prenatal Testing may be contradicted by other studies. A recent meta-analysis by Simopoulou et al. I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. We have one (and only one) 4bb PGS normal embryo. With both transfers I did estrogen tablets, progesterone in oil shots, blood thinner shots and low dose aspirin. Best of luck on your next FET! We are currently waiting on the PGS results from the frozens from our third cycle. Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid 1st IVF Cycle with initial low beta results, Day 6 Blastocysts / PGS / embryo "Hunger Games". What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. In large scale Double Blind Randomized Control Trials (the best method for medical protocol research) PGT did not increase your chances of pregnancy, except in some scenarios. what were the extra things you did besides Lovenox/prednisone, biopsy and ERA? Are there recent numbers for this comparison? (2014)found no difference inongoing pregnancybetween grades (about 50% for each category). Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. Hoping to hear from them soon . I've already previously had 2 hysteroscapies (previously had a uterine septum - one hysteroscapy removed it, the other confirmed there was no scar tissue left). After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. I know how devastating loss can be but theres always, always hope. My current success was a FET with NO meds except vaginal progesterone. Check here for the full glossary (please excuse the repeated terms!). MENTS THROUGHOUT MENTS So what gives now?? Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. Please whitelist our site to get all the best deals and offers from our partners. I was wondering what protocol were you on for your second transfer? So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. For <37, this was about 5, for 37-40 about 4, and for >40 about 3 (so older women tend to produce fewerblasts). Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. It's an autoimmune blood clotting disorder that can cause recurrent miscarriage. I have to say that I'm not 100% sure I needed any of the extra things we did- but I wanted to try whatever I could and these things couldn't hurt. I know I needed it after my failed FET and I really didnt have it. Wondering if anyones had a similar experience or has any advice. Sending you lots of love, hope and positivity! I only have embryo left ugh . There are many potential causes of an . Is it significantly less for a pregnancy with an embryo that tested pgt normal? 2nd was an FET that was a chemical, likely due to an embryo issue, even though it was graded highest. Consult with your doctor before making any treatment changes. I needed additional days of progesterone and that was corrected for my 2nd FET. Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. (2018)found a slight reduction inlive birth ratecompared to single biopsied embryos (50% vs 58%), but this was notstatistically significant. We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! A few rounds of heavy- duty antibiotics cleared it up. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. First, PGS improves pregnancy rates. Every positive thing helps! Took 2 years of "fighting" but looking back all the money, pain. I have one more embryo remaining. Its so heartbreaking but Im trying to find some hope so I can move forward. 2014). And my RE is kind of resistant to doing extra tests before I have a second failure, which I find a little crazy. We Tested the tissue and it was normal (??).
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