We may also contact the original authors to provide additional relevant information, if necessary. This review will be helpful to clinicians treating COVID-19 and asymptomatic infection may provide evidence for researchers. If there are latest published studies, they will be directly included in the comprehensive treatment together with previous studies. For RCTs, the Cochrane Collaboration's tool for assessing risk of bias will be used; 2. Lianhua Qingwen (LHQW), a Chinese supplement approved by thePhilippine Food and Drug Administration (FDA) for mild Covid-19 symptoms,continues togain popularity and controversy. However, there are individual differences in the efficacy of traditional Chinese medicine compound Lianhua Qingwen, which makes the quality of evidence of clinical efficacy of traditional Chinese medicine low. 13. Bethesda, MD 20894, Web Policies [4] However, at present, there is no effective antiviral treatment drug confirmed for covid-19. [26]. See this image and copyright information in PMC. This product is capsule, brown to yellowish brown particles and powder inside;smell slightly fragrant, slightly bitter taste. Disclaimer. All the prescriptions are used to clear the toxic heat in the lung, clear the lung qi, and cut off the disease. V03AX - Other therapeutic products ; Other products with therapeutic properties. In 2011, Diagnosis and Treatment Guide for Influenza (2011), issued by the Ministry of Health In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. 8600 Rockville Pike 11. The rate of positive nucleic acid detection of COVID-19 from intranasal and pharyngeal swabs was significantly lower in the treatment group Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. TheChinese researchers also claim thatLHQWisa classical Chinese medical preparation and that itscapsules or granulesareconsist of 11 herbs, gypsum,and mentholwhich are recorded in the2015 Edition ofthe ChinesePharmacopoeia. Clinical observation shows that the total effective rate of traditional Chinese medicine is >90%.[15]. Keyword Highlighting Study on the anti Staphylococcus aureus biofilm formation of Lianhuaqingwen capsule [J]. Molecules. Novel coronavirus pneumonia treatment plan (revised version 7) [EB/OL]. Also illustrates the potential biases within each of the included studies by presenting a risk of bias," table, graph, and summary. PRISMA flow diagram of study and exclusion. FOIA Placebo, routine western medicine therapy, and other therapeutic methods in the comparators (drugs, dose, frequency, duration); (5) Outcomes: the primary outcomes include total efficiency, primary symptoms, and Unable to load your collection due to an error, Unable to load your delegates due to an error. The conclusion of this review will provide evidence to judge whether Lianhua Qingwen combined with Conventional antiviral Western Medicine is an effective and safe intervention for COVID-19. Ding Y, Zeng L, Li R, et al. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. [19]. 9 Experimental research also showed that LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function. Lianhua Qingwen was developed by Shijiazhuang Yiling Pharmaceutical in 2003 as a treatment for severe acute respiratory syndrome (SARS) following the outbreak of the disease in 2002 and was listed by the National Health Commission of China in 2004 as a treatment for influenza and other respiratory disease. Is there any notice for taking Lianhua Qingwen Capsules? Remdesivir in adults with severe, [13]. Please enable it to take advantage of the complete set of features! Lianhua Qingwen Pregnancy & lactation. The Philippines Food and Drug Administration (FDA) has approved the traditional Chinese medicine (TCM) capsule Lianhua Qingwen widely used in China as Chinese drug Lianhua Qingwen is one of 3 treatments which are part of Chinas standard therapy for mild and moderate coronavirus patients. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health. Following the outbreak of Covid-19 in Wuhan, a randomized clinical study, led by top TCM physicians, was conducted to study its efficacy in treating Covid-19. [31] The results will be interpreted carefully based on several explanations for funnel plot asymmetry. Chest radiographs. sharing sensitive information, make sure youre on a federal Asia's one-stop resource for medical news, clinical reference and education, Click to view Lianhua Qingwen detailed prescribing information. < 5 years: not recommended because it may be difficult for young children to swallow capsules. Federal government websites often end in .gov or .mil. The effect of Lianhuaqingwen Capsule on the expression of inflammatory factors and connexin in lipopolysaccharide induced acute lung injury mice [J]. your express consent. [14]. Search for Similar Articles Preliminary study on the inhibitory effect of three prescriptions of traditional Chinese medicine on SARS related coronavirus in vitro [J]. Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. Xiaoyan Liu. Early Treatment>14 years & above:4capsules x 3 times a day ( after breakfast, lunch and dinner) for7 to 10 days. Do not give during pregnancy & lactation, & in childn. We will judge the each domain as low risk of bias, high risk of bias," or uncertain risk of bias" according to Higgins (2011), and pay particular attention to the risk of bias of cluster-randomised trials. Before the evaluation results of this system are published, all databases will be retrieved again. Avoid receiving nourishing Chinese medicine during the period in this product. Wang DC, Yu M, Xie WX, Huang LY, Wei J, Lei YH. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsuleare as follows: First, after taking the capsule, patients' symptoms improve quickly, recovery rate up to 91.5%, conversion to severe cases down to 2.1%. A: Chest radiograph of normal people; B: Chest radiograph of a patient with early-mid-stage COVID-19. Wu Yiling. While it has been included in the standard treatment for coronavirus patients in China, it faces hurdles in the West where scientists raise questions over the evidence and effectiveness of traditional medicine. [Administration and Dosage]For oral administration, 4 capsules once, 3 times daily. Exclusion: studies using two or more Chinese herbal compound as intervention measures will be excluded. In 2018, Diagnosis and Treatment Scheme for Influenza (2018), issued by the National Health and Family Planning Commission The studies that do not fulfill the inclusion criteria will be excluded and listed with reasons for their exclusion. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. [Efficacy and safety of Lianhua Qingwen capsule for influenza a Data is temporarily unavailable. Second Prize of National Science and Technology Progress Awards If substantial heterogeneity is identified, we will report it and explore possible causes using sensitivity analysis and subgroup analysis. COVID-19; Lianhua Qingwen; clinical symptoms; retrospective study; total effective rate; traditional Chinese medicine (TCM) treatment. Please try after some time. 2011. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. Cao B, Zhang D, Wang C. A trial of lopinavir-ritonavir in, [6]. [Package]Aluminium-plastic package, 24 capsules/box, [Executive Standard]Chinese Pharmacopoeia 2010, the 2nd supplemental volume. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). Measuring inconsistency in meta-analyses. Conclusion: [24]. Preliminary study on the inhibitory effect of three traditional Chinese medicine prescriptions on SARS related coronavirus in vitro [J]. National Library of Medicine If I2 test 50%, a random-effects model will be used for data analysis instead. For NRIs, evaluate its methodological quality with the Newcastle Ottawa scale (NOS). A: Chest radiograph of normal people; B: Chest radiograph of a. As stated in the research paper published on "Scientific World Journal", Lianhua-Qingwen capsule (LQC) is a commonly used Chinese medical preparation to treat virus and especially played a very important role in the fight against severe acute respiratory syndrome (S-A-R-S) in 2002-2003 in China. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in the control group (n=33). (For Children 4 to 18 years of age): 3 times daily. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment course. All relevant data are within the article and its supporting information files. Just because a supplement is derived from natural sources does not mean it is safe. Please be informed that only the The Daily Guardian is a renascent Iloilo-based publishing firm and media outfit with bureaus in Kalibo, Boracay, Roxas, Bacolod, Antique, Guimaras, and Manila. Efficacy and safety of herbal medicine (Lianhuaqingwen) for [22]. 4 capsules per dose. 2020;99:30(e21404). Pharmacology and clinical research of traditional Chinese medicine 2010;26:214. Chest radiographs of the patient. 5.Children, preganant or lactation women,elderly ,feeble and weak patients ,spleen and stomach weakness patients should be taken under the guidance of physician. WHO Director-General's opening remarks at the media briefing on. 7. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsule are as follows: First, In 2014, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (2014), issued by the National Health and Family Planning Commission In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. She can be reached atbandiolateresamayb@gmail.com. Upgrade to Rappler+ for exclusive content and unlimited access. Would you like email updates of new search results? Contraindicated for the patients allergic to this product, be cautions about patients with allergic constitution. The manuscript was drafted by XLZ and MJL. However, this systematic review will have some limitations. If I2 test <50%, a fixed-effects model will be used to pool the data. [Description]Capsules, containing tan to brown granule and powder; odour, slightly aromatic; taste, slightly bitter. Objective: Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. official website and that any information you provide is encrypted 10. PMC eCollection 2023. Dichotomous outcomes will be presented as risk ratio and 95% confidence intervals (CIs), and continuous outcomes will be presented as mean difference/standard mean difference and 95% CIs. Lianhua Qingwen | Yiliang Lianhua Qingwen Jiaonang [18]. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. FDA Director General Eric Domingo likewise confirmed the approval of Lianhua Qingwen in a text message to Rappler on Wednesday afternoon. Children should be administered under adults supervision. [1]. WebDrug Name Lianhua Qingwen Capsules; Approval No. GYZZ Z20040063; Strength 0.35g/capsule; Administration and Dosage For oral administration, 4 capsules once, 3
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